https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 PP2Ac Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2Ac Modifications Including Leu309 Methylation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45285 Wed 26 Oct 2022 17:27:09 AEDT ]]> Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45196 Wed 26 Oct 2022 15:23:03 AEDT ]]> A Novel Role of PP2A Methylation in the Regulation of Tight Junction Assembly and Integrity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52191 Wed 15 May 2024 15:47:17 AEST ]]> A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51830 Wed 15 May 2024 15:34:41 AEST ]]> Advantages of array-based technologies for pre-emptive pharmacogenomics testing https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29574 Wed 11 Apr 2018 14:11:09 AEST ]]> Protein phosphatase 2A dysfunction in Alzheimer's disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21291 in vivo and in AD. Disruption of PP2A/Bα-Tau protein interactions likely contribute to Tau deregulation in AD. Significantly, alterations in one-carbon metabolism that impair PP2A methylation are associated with increased risk for sporadic AD, and enhanced AD-like pathology in animal models. Experimental studies have linked deregulation of PP2A methylation with down-regulation of PP2A/Bα, enhanced phosphorylation of Tau and amyloid precursor protein, Tau mislocalization, microtubule destabilization and neuritic defects. While it remains unclear what are the primary events that underlie "PP2A" dysfunction in AD, deregulation of PP2A enzymes definitely affects key players in the pathogenic process. As such, there is growing interest in developing PP2A-centric therapies for AD, but this may be a daunting task without a better understanding of the regulation and function of specific PP2A enzymes.]]> Wed 11 Apr 2018 12:53:23 AEST ]]> Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16003 Wed 11 Apr 2018 12:17:35 AEST ]]> PP2A methylation controls sensitivity and resistance to ß-amyloid-induced cognitive and electrophysiological impairments https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30261 Wed 11 Apr 2018 10:01:07 AEST ]]> Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43277 Thu 15 Sep 2022 12:09:32 AEST ]]> Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9584 Sat 24 Mar 2018 08:39:11 AEDT ]]> Cocaine regulates the salt-inducible kinase (SIK1) by inducing protein phosphatase-2A expression in rat brain https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19410 Sat 24 Mar 2018 07:52:06 AEDT ]]> Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20150 Sat 24 Mar 2018 07:51:36 AEDT ]]> Acute administration of L-dopa induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25987 Sat 24 Mar 2018 07:37:00 AEDT ]]> Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52534 Mon 16 Oct 2023 14:56:57 AEDT ]]> Protein phosphatase 2A: more than a passenger in the regulation of epithelial cell-cell junctions https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42190 Fri 26 Aug 2022 09:08:16 AEST ]]>